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A TREATMENT FOR ADULTS WITH TYPE 2 DIABETES MELLITUS, IN ADDITION TO DIET AND EXERCISEDosing & Administration

CONVENIENT ONCE-DAILY DOSING

The first sodium-glucose cotransporter 2 (SGLT2) inhibitor + metformin combination therapy available in extended release for once-daily dosing1
 
  • ONCE-DAILY DOSING
  • TAKEN IN THE MORNING WITH FOOD

Multiple dosing options available for individualized patient treatment:

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  • Gradual dose escalation is recommended to reduce GI side effects of metformin
  • Tablets must be swallowed whole and never crushed, cut, or chewed
  • The maximum daily recommended dose is 10 mg for dapagliflozin and 2000 mg for metformin
  • Patients taking an evening dose of metformin XR should skip their last dose before starting XIGDUO XR
  • In patients with volume depletion, correcting this condition prior to initiation of XIGDUO XR is recommended
  • Before initiation of XIGDUO XR, and periodically thereafter, renal function should be assessed. XIGDUO XR is contraindicated in patients with an eGFR <60 mL/min/1.73 m2

The 10-mg/2000-mg dose is administered as two 5-mg/1000-mg tablets once-daily.

  • Acute Kidney Injury and Impairment in Renal Function: Dapagliflozin causes intravascular volume contraction and renal impairment, with reports of acute kidney injury requiring hospitalization and dialysis. Consider temporarily discontinuing in settings of reduced oral intake or fluid losses. If acute kidney injury occurs, discontinue and promptly treat.

    Dapagliflozin increases serum creatinine and decreases eGFR. Elderly patients and patients with impaired renal function may be more susceptible to these changes. Before initiating XIGDUO XR, evaluate renal function and monitor periodically. XIGDUO XR is contraindicated in patients with an eGFR <60 mL/min/1.73 m2.

WHEN TREATMENT WITH BOTH DAPAGLIFLOZIN AND METFORMIN IS APPROPRIATE IN ADDITION TO DIET AND EXERCISE

START EARLY WITH XIGDUO XR

Consider XIGDUO XR for patients who:
  • Need A1C reduction beyond monotherapy*
  • Could also benefit from weight reduction
XIGDUO XR is not indicated for weight loss.

*Vs metformin XR or dapagliflozin.